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Mouse anti‑Rat CD71 / Transferrin Receptor IgG2a Monoclonal RW-C43741-0.5

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Antibody: CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (Low Endotoxin) (OX-26) Antibody, Application: IHC-P, IHC-Fr, IF, WB, Flo, Reactivity: Rat, Format: Unconjugated, Low Endotoxin, Descriptio: Transferrin Receptor antibody RW-C43741 is an unconjugated mouse monoclonal antibody to rat Transferrin Receptor (CD71). Validated for Flow, IF, IHC and WB., Targe: Rat CD71 / Transferrin Receptor, Synonym: TFRC | CD71 | TFR1 | TRFR | TFR | TR | CD71 antigen | p90 | T9 | Transferrin receptor | Transferrin receptor protein 1, Hos: Mouse, Reactivit: Rat (tested or 100% immunogen sequence identity), Clonalit: IgG2a Monoclonal, Clon: OX-26, Conjugation: Unconjugated, Purificatio: Protein G purified, Modification: Low Endotoxin, Immunoge: PHA activated rat lymphocytes, Specificit: Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialized proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer's€™s, Parkinson's, Huntington's and Multiple Sclerosis. Is reported as suitable for use in immunoelectron microscopy. OX-26 detects a band of ~95kD in Western blotting under reducing conditions and ~195kD under non-reducing conditions reflecting it's homodimeric structure., Application: IHC - Paraffin
IHC - Frozen
Immunofluorescence
Western blot
Flow Cytometry (1:10 - 1:100), Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Usag: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request., Presentatio: PBS, Storag: Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About CD71 / Transferrin Recepto: Uniprot: P02786 NCBI: NM_003234 NP_003225.2

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    Cat: RW-73-81331-288