Mouse anti‑Human DES / Desmin IgG1 Monoclonal RW-B14848-0.05

Antibody: DES / Desmin Mouse anti-Human Monoclonal (D33) Antibody, Application: IHC, IHC-P, IHC-Fr, ICC, WB, Reactivity: Human, Rat, Dog, Hamster, Horse, Pig, Chicken, Cow, Format: Unconjugated, Unmodified, Descriptio: Desmin antibody RW-B14848 is an unconjugated mouse monoclonal antibody to Desmin (DES) from human. It is reactive with human, rat, chicken and other species. Validated for ICC, IHC and WB. Tested on 20 paraffin-embedded human tissues., Targe: Human DES / Desmin, Synonym: DES | ARVC7 | ARVD7 | CMD1I | CSM1 | CSM2 | MFM1 | SCPNK | Desmin | Intermediate filament protein, Hos: Mouse, Reactivit: Human, Rat, Dog, Hamster, Horse, Pig, Chicken, Cow (tested or 100% immunogen sequence identity), Clonalit: IgG1 Monoclonal, Clon: D33, Conjugation: Unconjugated, Purificatio: Purified, Modification: Unmodified, Immunoge: D33 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a BALB/c mouse immunized with purified desmin from a leiomyosarcoma., Specificit: The antibody D33 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e. g. rhabdomyosarcoma and leiomyosarcoma in human, hamster, rat and chicken. The antibody does not cross react with vimentin or any of the other intermediate filament proteins., Application: IHC
IHC - Paraffin (10 µg/ml)
IHC - Frozen
ICC
Western blot, Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Usag: Desmin is a 53 kD intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i. e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed., Presentatio: PBS, 0.09% Sodium Azide, Storag: Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About DES / Desmi: Uniprot: P17661 NCBI: NM_001927 NP_001918.3

Cat: RW-73-128712-149