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Mouse anti‑Rat CYCS / Cytochrome c IgG1,k Monoclonal RW-C390827-100
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Antibody: CYCS / Cytochrome c Mouse anti-Rat Monoclonal (Azide-free, BSA-free) (6H2.B4) Antibody, Application: IF, WB, Flo, Reactivity: Rat, Human, Mouse, Format: Unconjugated, Azide-free, BSA-free, Other formats: Unmodified, Descriptio: Cytochrome c antibody RW-C390827 is an unconjugated mouse monoclonal antibody to Cytochrome c (CYCS) from rat. It is reactive with human, mouse and rat. Validated for Flow, IF and WB., Targe: Rat CYCS / Cytochrome c, Synonym: CYCS | CYC | HCS | THC4 | Cytochrome c | Cytochrome c, somatic, Hos: Mouse, Reactivit: Rat, Human, Mouse (tested or 100% immunogen sequence identity), Clonalit: IgG1,k Monoclonal, Clon: 6H2.B4, Conjugation: Unconjugated, Purificatio: Protein G purified, Modification: Azide-free, BSA-free. Also available Unmodified., Immunoge: Rat full-length protein., Specificit: Rat CYCS / Cytochrome c, Application: Immunofluorescence (0.5 - 1 µg/ml)
Western blot
Flow Cytometry (0.5 - 1 µg/10E6 cells), Usag: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. Optimal dilution of the Cytochrome C antibody should be determined by the researcher., Presentatio: 1X PBS, Storag: Store at 2°C to 8°C., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About CYCS / Cytochrome : Uniprot: P99999 NCBI: NM_018947 NP_061820.1

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    Cat: RW-73-117221-217