严窝瘟 纤劳刃温劳冗 团梢形-抢章酪臀 遗欣先

严窝瘟 纤劳刃温劳冗 团梢形-抢章酪臀 遗欣先


RU (11) 2212260 (13) C2

(51) 7 A61N5/10, A61B6/03 

(12) 蜗妊劳扰 惹瘟信遗腿 侠遗鸵 形蜒壬咽紊 耘呐欣秩 
羊囹篑: 镱 溧眄 磬 07.09.2007 - 镳尻疣蜩 溴轳蜮桢 

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(14) 泥蜞 矬犭桕圉梃: 2003.09.20 
(21) 绣汨耱疣鲨铐睇 眍戾 玎怅: 2001111347/14 
(22) 泥蜞 镱溧麒 玎怅: 2001.04.26 
(24) 泥蜞 磬鬣豚 铗聍弪 耩铌 溴轳蜮 镟蝈眚: 2001.04.26 
(43) 泥蜞 矬犭桕圉梃 玎怅: 2003.02.27 
(45) 物筢腓觐忄眍: 2003.09.20 
(56) 理嚯钽 桤钺疱蝈龛: IMAHORI Y. et al. Positron emission tomography - based boroncapture therapy using boronophenyl a1anine for high - grade gliomas. Clin. Cancer Res. - 1998, v.4, No.8, p.1825- 1841. RU 2141860 C1, 27.11.1999. SU 695280 A1, 27.02.2000. 
(71) 褥 玎忤蝈: 体滂鲨眈觇 疣滂铍钽梓羼觇 磬篦睇 鲥眚 欣掏 
(72) 褥 桤钺疱蜞蝈: 与礤黻 ..; 暑觇 ..; 咪痤怦赅 ..; 燕忤磬 ..; 妙疳篪桧 .. 
(73) 褥 镟蝈眚铑犭噤囹咫: 体滂鲨眈觇 疣滂铍钽梓羼觇 磬篦睇 鲥眚 欣掏 
(98) 冷疱 潆 镥疱镨耜: 249020, 枢塍骜赅 钺., . 吾龛眈, 箅. 暑痤脲忄, 4, 体滂鲨眈觇 疣滂铍钽梓羼觇 磬篦睇 鲥眚 欣掏 

(54) 严窝瘟 纤劳刃温劳冗 团梢形-抢章酪臀 遗欣先 

如钺疱蝈龛 铗眍耔蝰 戾滂鲨礤, 桁屙眍 钺豚耱 塍麇忸 蝈疣镨, 镳邃磬珥圜屙 潆 镫囗桊钼囗 礤轵痤-玎踱囹眍 蝈疣镨. 骡钿 蝮祛痤蝠铒睇 镳屣囵囹 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍, 戾麇眄 汔祆-桤塍鬣蝈脲. 如戾 滂磬扈牦 磬觐镫屙 恹忮溴龛 镳屣囵囹 镱祛 汔祆-蝾祛沭圄 玎蝈 恹徼疣 怵屐屙眍 桧蝈疴嚯 潆 镳钼邃屙 礤轵痤-玎踱囹眍 蝈疣镨 镳 篑腩忤, 觐沅 杨矬躅朦(t)/羊赅睃(t)>1 杨矬躅朦(t)>min杨矬躅朦>羊赅睃(t), 沅 杨矬躅朦(t) 羊赅睃(t) - 觐眦屙蝠圉 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍 铒篚铍 铌痼驵桴 蜿囗, min杨矬躅朦 -扈龛爨朦磬 觐眦屙蝠圉 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍 铒篚铍, 镳 觐蝾痤 钺塍麇龛 蝈镫钼 礤轵痤磬扈 纛痨桊箦 翦牝桠眢 镱汶铢屙眢 漕珞. 朽耨麒螓忄 祛铖螯 漕琨 桤塍麇龛, 镱怆邈铖 疱珞朦蜞蝈 疱嚓鲨 礤轵痤眄钽 玎踱囹. 蔫磬扈牦 磬觐镫屙 戾麇眍泐 耦邃桧屙 桉耠邃簋 滂囡噻铐 铗 祛戾眚 忖邃屙 漕 48 . 填铖螯 漕琨 铒疱溴 镱 耦铗眍龛 =(杨矬躅朦NA/)攀, 沅 - 祛铖螯 漕琨, 衩/; - 镫铗眍耱 镱蝾赅 蝈镫钼 礤轵痤眍, /(耢2); NA - 麒耠 棱钽噤痤; -祛脲牦痦 爨耨 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍; - 皴麇龛 玎踱囹 蝈镫钼 礤轵痤眍, 耢2; - 屦汨 铗 镳钿箨蝾 疱嚓鲨, 听; - 觐翳鲨屙 耦汶囫钼囗 疣珈屦眍耱彘 - 1,610-8 衩疸/听. 扬铖钺 镱玮铍弪 镳钼钿栩 桧滂忤潴嚯铄 镫囗桊钼囗桢 礤轵痤-玎踱囹眍 蝈疣镨 镳 脲麇龛 犷朦睇 耦 耠铈睇扈 纛痨囔 珉铌圜羼蜮屙睇 眍忸钺疣珙忄龛. 2 ..-臌, 1 蜞犭., 3 桦. 


蜗妊劳扰 惹瘟信遗腿



如钺疱蝈龛 铗眍耔蝰 钺豚耱 塍麇忸 蝈疣镨, 鬣耱眍耱 礤轵痤-玎踱囹眍 蝈疣镨 (颓), 桉镱朦珙忄龛屐 镳屣囵囹钼, 耦溴疰帙桴 蹊扈麇耜桢 屐屙螓 犷朦 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍.

如忮耱屙 耧铖钺 镫囗桊钼囗 礤轵痤-玎踱囹眍 蝈疣镨 (颓) 磬 铖眍忮 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 钺疣琏圊 蜿囗彘 镱耩邃耱忸 囹铎眍-桉耔铐眍 耧尻蝠铖觐镨 桧潴牝桠眍 疋玎眄铋 镫噻祛 [1]. 洋铖螯 耧铖钺 蝾, 黩 祉钽桢 蹊扈麇耜桢 屐屙螓 镳 忸玑箧溴龛 桉矬耜帼 桤塍麇龛 踵疣牝屦睇扈 潆桧囔 忸腠. 物疱溴脲龛 觐腓麇耱忄 犷疣 铖眍忄眍 磬 镨痂麇耜铋 玎忤耔祛耱 戾驿 桧蝈眈桠眍耱 桉矬耜噱祛泐 桤塍麇龛 镳 铒疱溴脲眄 潆桧圊 忸腠 觐腓麇耱忸 屐屙蜞 钺疣琏 蜿囗. 蒡铗 耧铖钺 怅膻鬣弪: 1) 铗犷 钺疣琏钼 铒篚铍 蜿囗彘; 2) 镱溷铗钼牦 泐祛沐眄 疣耱忸痤; 3) 怙瘥耜桠囗桢 镳钺 镫噻祗 (=8000 ), 钺疣珞簋 玎 聍弪 镥疱溧麒 屦汨 恹耦觐鬣耱铗眍泐 镥疱戾眄钽 镱 汔珞 (囵泐) 镱耩邃耱忸 爨沩栩眍 桧潴牿梃; 4) 翳犟桊钼囗桢 磬 耧尻蝠钽疣翦 桤塍麇龛 犷疣 镳 潆桧 忸腠 249,678 盱; 5) 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 铒篚铍 磬 祛戾眚 钺塍麇龛 蝈镫钼 礤轵痤磬扈 镱 箴钼睨 犷疣 牮钼 镱 疣礤 篑蜞眍怆屙眍祗 耦铗眍龛 (犷 铒篚铍)/(犷 牮钼).

湾漕耱囹赅扈 耧铖钺 怆:

1) 珥圜栩咫 玎蝠囹 怵屐屙 磬 镳桡铗钼脲龛 钺疣琏钼 犷朦 蝠箐铄礻铖螯 镳 镳钼邃屙梃 囗嚯栩梓羼觇 桉耠邃钼囗栝;

2) 镳钼邃屙桢 囗嚯桤 蝾朦觐 铗溴朦睇 戾滂觐-徼铍钽梓羼觇 钺疣琏圊 (in vitro);

3) 钿眍疣珙恹 铗犷 钺疣琏钼 蜿囗 潆 囗嚯桤 (镳 镳钼邃屙梃 蹊痼疸梓羼觐 铒屦圉梃) 赅 耠邃耱忤 礤忸珈铈眍耱 镳祛泐 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 疣珥 耩铌 镱耠 忖邃屙 犷瘃钿屦驵泐 镳屣囵囹.

如忮耱屙 耧铖钺 镫囗桊钼囗 颓 磬 铖眍忮 铒疱溴脲龛 觐腓麇耱忄 犷疣 戾蝾漕 礤轵痤-嚓蜩忄鲨铐眍 疣滂钽疣翳 [2, 3] . 橡 铎 桉镱朦珞 蜮屦漕蝈朦睇 蝠尻钼 溴蝈牝铕 (疣珥 蜩稃 镱腓戾痦 镫屙铌) 潆 铞屙觇 疣耧疱溴脲龛 觐腓麇耱忮眄钽 耦溴疰囗 蜿囗 10, 钺豚溧邈 犷朦 皴麇龛屐 玎踱囹 疱嚓鲨 10(n,,)7Li. 吾疣珞桢 镳 铎 -鬣耱桷 恹琨忄 镱怵彐溴龛 溴蝈牝铕 镱怆屙桢 磬 邈 镱忮瘐眍耱 箅疣扈牮铑蜮屦耱栝 - 蝠尻钼, 觐蝾瘥 囗嚯桤桊簋 磬 铒蜩麇耜铎 扈牮铖觐镥. 暑腓麇耱忸 蝠尻钼 镳铒铕鲨铐嚯 觐眦屙蝠圉梃 犷疣 钺疣琏. 蒡铗 戾蝾 怅膻鬣弪: 1) 铗犷 钺疣琏钼 铒篚铍, 蜿囗彘, 牮钼; 2) 镳桡铗钼脲龛 桤 钺疣琏钼 恹耋眄, 耧疱耨钼囗睇 蜞犭弪铌; 3) 牮屣脲龛 镱忮瘐眍耱 蜞犭弪铌 溴蝈牝铕钼; 4) 钺塍麇龛 礤轵痤磬扈; 5) 囗嚯桤 钺疣珙忄怿桴 蝠尻钼 磬 铒蜩麇耜铎 扈牮铖觐镥; 6) 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 铒篚铍 磬 祛戾眚 镳钼邃屙 颓 镱 箴钼睨 犷疣 牮钼 镱 疣礤 篑蜞眍怆屙眍祗 耦铗眍龛 (犷 铒篚铍)/(犷 牮钼). 湾漕耱囹赅扈 耧铖钺 怆:

1) 潆栩咫铖螯 (6-7 漤彘) 耠铈眍耱 囗嚯桤;

2) 礤钺躅滂祛耱 桉镱朦珙忄龛 桉蝾黜桕 蝈镫钼 礤轵痤眍 潆 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣;

3) 镳钼邃屙桢 囗嚯桤 蝾朦觐 in vitro;

4) 钿眍疣珙恹 铗犷 钺疣琏钼 蜿囗 潆 囗嚯桤 (镳 镳钼邃屙梃 蹊痼疸梓羼觐 铒屦圉梃 赅 耠邃耱忤 礤忸珈铈眍耱 镳祛泐 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 疣珥 耩铌 镱耠 忖邃屙 犷瘃钿屦驵泐 镳屣囵囹.

如忮耱屙 耧铖钺 镫囗桊钼囗 颓 镱祛 觐腓麇耱忮眄钽 铒疱溴脲龛 犷疣 镱耩邃耱忸 耧尻蝠铎弪痂 煦眍忮眄钽 汔祆-桤塍麇龛 [4, 5]. 暑眦屙蝠圉棹 铒疱溴 礤犷朦 戾滂觐-徼铍钽梓羼觇 钺疣琏圊 鲥腩耱眍 铕汔龛珈. 扬铖钺 铖眍忄 磬 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣 礤镱耩邃耱忮眄 镳铞羼皴 钺塍麇龛 钺疣琏钼 蝈镫钼 礤轵痤磬扈 (n) 镱 疱汨耱疣鲨 煦眍忮眄钽 汔祆-桤塍麇龛 铗 疱嚓鲨 n+10-->7Li+4湾+. 软蝈眈桠眍耱 桉矬耜噱祛泐 汔祆-桤塍麇龛 镳铒铕鲨铐嚯 觐眦屙蝠圉梃 犷疣 钺疣琏. 蒡铗 耧铖钺 怅膻鬣弪: 1) 忖邃屙桢 铕汔龛珈 犷瘃钿屦驵泐 镳屣囵囹; 2) 铗犷 镱溷铗钼赅 钺疣琏钼 徼铍钽梓羼觇 蜿囗彘 ( 耠篦噱 in vitro); 3) 钺塍麇龛 钺疣琏钼 蜿囗 桦 骅忸泐 铕汔龛珈 矬麝铎 蝈镫钼 礤轵痤眍 桤 疱嚓蝾疣; 4) 疱汨耱疣鲨 汔祆-桤塍麇龛. 项塍麇眄 溧眄 觐眦屙蝠圉梃 犷疣 铒篚铍 镱玮铍 觐痧尻蜩痤忄螯 祛铖螯 漕琨 蝈镫钼 礤轵痤眍 镳 镳钼邃屙梃 颓. 湾漕耱囹赅扈 耧铖钺 怆:

1) 礤钺躅滂祛耱 桉镱朦珙忄龛 桉蝾黜桕 蝈镫钼 礤轵痤眍 潆 铒疱溴脲龛 觐眦屙蝠圉梃 犷疣;

2) 祉钽铌疣蝽 塍麇忄 磬沭箸赅 磬 铕汔龛珈 (钺塍麇龛 磬 疱嚓蝾疱) 镳 桤篦屙梃 滂磬扈觇 磬觐镫屙 犷瘃钿屦驵泐 镳屣囵囹;

3) 恹耦赅 耱铊祛耱 疱嚯桤圉梃 耧铖钺.

橡铗铗栾铎 镳邃豚汔屐钽 蝈蹴梓羼觐泐 疱龛 怆弪 耧铖钺 镫囗桊钼囗 颓 磬 铖眍忮 觐腓麇耱忮眄钽 铒疱溴脲龛 犷疣 铕汔龛珈 镱祛 镱玷蝠铐眍 桉耔铐眍 蝾祛沭圄梃 [6]. 蒡铗 耧铖钺 铖眍忄 磬 桉镱朦珙忄龛 赅麇耱忮 疣滂钹牝桠眍 戾蜿 镱玷蝠铐-桤塍鬣桴 箅疣觐痤蜿铈桠簌桴 桤铗铒钼, 觐蝾瘥 觐祜脲犟 犷瘃钿屦驵扈 耦邃桧屙扈 忖钿 铕汔龛珈. 项玷蝠铐 囗龛汨腓痼弪 尻蝠铐铎, 黩 耦镳钼铈溧弪 恹溴脲龛屐 溻篚 纛蝾眍, 疱汨耱痂痼屐 镱祛 耔耱屐 溴蝈牝铕钼. 暑祜蝈痦 钺疣犷蜿 镱塍麇眄 溧眄 镱玮铍弪 镳邃耱噔栩 赅痱桧 钺祉钽 疣耧疱溴脲龛 犷疣 骅忸 铕汔龛珈 疣耨麒蜞螯 邈 觐眦屙蝠圉棹 铒篚铍 铌痼驵桴 蜿囗. 蒡铗 耧铖钺 怅膻鬣弪: 1) 耔眚彗 戾麇眍泐 镱玷蝠铐-桤塍鬣邈 桤铗铒 (18F) 犷瘃钿屦驵 耦邃桧屙桢, 潆 觐蝾痤泐 爨犟桁箪 磬觐镫屙 犷疣 铒篚铍 镳桴钿栩 磬 镥疴 鬣覃 镱耠 忖邃屙 (磬镳桁屦, 犷痿屙桦嚯囗桧 (滦)); 2) 忖邃屙桢 戾麇眍泐 耦邃桧屙 铕汔龛珈, 3) 桉耠邃钼囗桢 磬觐镫屙 犷疣 铒篚铍 磬 镱玷蝠铐-桉耔铐眍 蝾祛沭圄; 4) 觐祜蝈痦 囗嚯桤, 镱玮铍栝 铒疱溴螯 觐眦屙蝠圉棹 犷疣 铒篚铍 铗眍龛 (犷 铒篚铍)/(犷 铌痼驵桴 蜿囗) 磬 镳铗驽龛 镥疴 鬣耦 (0-6 ) 祛戾眚 忖邃屙 戾麇眍泐 镳屣囵囹.

湾漕耱囹赅扈 耧铖钺 怆:

1) 猁耱瘥 疣耧噤 镱玷蝠铐-桤塍鬣桴 桤铗铒钼, 黩 桉觌噱 忸珈铈眍耱 耔眭痤龛玷痤忄螯 镳铞羼 翳玷麇耜钽 疣耧噤 桤铗铒钼 觇礤蜩觐 磬觐镫屙 镳屣囵囹钼, 觐蝾瘥 爨犟桁箪 磬觐镫屙 犷疣 铒篚铍 镳桴钿栩 磬 犷脲 镱玟龛 耩铌;

2) 礤钺躅滂祛耱 镳桠脲麇龛 耧弼栲腓耱钼 疣珥钽 镳铘桦;

3) 礤钺躅滂祛耱 耦忪妁屙 钿眍 磬篦眍 鲥眚疱 鲨觌铗痤磬, 豚犷疣蝾痂 镱 耔眚彗 戾麇眍泐 犷瘃钿屦驵泐 耦邃桧屙 镱玷蝠铐-桉耔铐眍泐 蝾祛沭圄;

4) 恹耦赅 耱铊祛耱 疱嚯桤圉梃 耧铖钺.

皱朦 桤钺疱蝈龛 怆弪 篑蝠囗屙桢 礤漕耱囹觐 镳铗铗栾 钺羼镥麇龛 忸珈铈眍耱 铒疱溴脲龛 铒蜩爨朦眍泐 耦铗眍龛 戾驿 耦溴疰囗桢 犷疣 铒篚铍 铌痼驵桴 蜿囗 蝈麇龛 镳钿铍骅蝈朦眍泐 怵屐屙 祛戾眚 忖邃屙 铕汔龛珈 犷瘃钿屦驵泐 耦邃桧屙.

碾 漕耱桄屙 箨噻囗眍 鲥腓 耧铖钺, 怅膻鬣屐 忖邃屙桢 铕汔龛珈 蝮祛痤蝠铒眍泐 犷瘃钿屦驵泐 镳屣囵囹, 桤戾疱龛 滂磬扈赍 磬觐镫屙桢 犷疣 铒篚铍 铌痼驵桴 蜿囗, 桉镱朦珞 赅麇耱忮 戾蜿 犷瘃钿屦驵泐 镳屣囵囹 汔祆-桤塍鬣蝈朦, 磬镳桁屦 桤铗铒 轭溧. 项 忮腓麒礤 邈 疣滂钹牝桠眍耱 镱祛 汔祆-蝾祛沭圄 桤戾 滂磬扈牦 磬觐镫屙 犷疣 蝈麇龛 礤耜铍桴 耋蝾. 橡 铎 镱耠 漕耱桄屙 爨犟桁嚯钽 磬觐镫屙 疣滂铋钿 铒篚铍 镱 耦铗眍龛 觐眦屙蝠圉梃 犷疣 铒篚铍 铌痼驵桴 蜿囗 玎溧 铒蜩爨朦睇 疱骅 礤轵痤-玎踱囹眍 蝈疣镨.

襄疱麇睃 翳泱:

澡. 1. 疏礤蜩赅 疣耧疱溴脲龛 戾麇睇 犷瘃钿屦驵 耦邃桧屙栝 铒篚铍:

1 - 蝮祛痤蝠铒眍 耦邃桧屙桢, 戾麇眄铄 桤铗铒铎 轭漕 (131I-BSH);

2 - 蝮祛痤蝠铒眍 耦邃桧屙桢, 戾麇眄铄 镱玷蝠铐 - 桤塍鬣桁 桤铗铒铎 (18F-BPA).

澡. 2. 朽耧疱溴脲龛 戾麇眍泐 犷瘃钿屦驵泐 耦邃桧屙 (131I-BSH) 蜿囗:

1 - 磬觐镫屙桢 铒篚铍;

2 - 磬觐镫屙桢 铌痼驵彘 蜿囗;

3 - 钺豚耱, 觐蝾痤 祛骓 镳钼钿栩 礤轵痤-玎踱囹眢 蝈疣镨.

澡. 3. 暑祜蝈痦铄 桤钺疣驽龛 豚镪 铒篚铍, 镱塍麇眄铄 潆 蝾麝 24 :

1 - 铌痼驵 蜿囗; 2 - 铒篚铍; 3 - 铕汔睇 恹忮溴龛.

橡桁屦 疱嚯桤圉梃 耧铖钺

橡桁屦 1. 镳邃豚汔屐铎 蝈蹴梓羼觐 疱龛 桉镱朦珙忄眍 蝮祛痤蝠铒眍 犷瘃钿屦驵 耦邃桧屙桢, 戾麇眄铄 汔祆-桤塍鬣蝈脲 (戾痍囡蝾漕溴赅犷疣 磬蝠 Na2B12H11SH(BSH), 戾麇眄 131I (131I-BSH)). 氧屐 邈 耔眚彗 祛驽 猁螯 镳邃耱噔脲磬 耠邃簋 忤溴:



卿羼 蹼铕桉螓 轭, 戾麇眄 轭漕-131, 镱塍鬣腓 桤铗铒睇 钺戾眍 礤疣滂钹牝桠眍泐 IC1 (HICl2) Na131I 镳 镳铖蝾 耢屮屙梃 桴 忸漤 疣耱忸痤. 绣嚓鲨彘 S-祛眍蜩箴铐桢忸泐 镳铊玮钿眍泐 漕溴赅犷疣蜞 (I) 戾麇眄 蹼铕桉螓 轭漕 镳 觐祉囹眍 蝈祜屦囹箴 镱塍鬣腓 戾麇眍 耦邃桧屙桢 (II), 觐蝾痤 徨 恹溴脲龛 钺疣徉螓忄腓 忸漤 疣耱忸痤 饰 潆 镱塍麇龛 耦邃桧屙 (III), 耦溴疰帙邈 镳铟眢 疋琰 犷 - 轭 (-I). 朽滂铛桁梓羼觇 恹躅 钽 耦邃桧屙 耦耱噔桦 95-97%.

脏痨嚓铌桧弪梓羼觇 桉耠邃钼囗 镱赅玎腓, 黩 131I-BSH 漕耱囹铟眍 漕脬 玎溴疰桠噱蝰 铒篚铍 (蜞犭. 1).

耦铗忮蝰蜮梃 镳铗铗栾铎 桉镱朦珙忄龛 犷瘃钿屦驵 耦邃桧屙栝, 戾麇眄 镱玷蝠铐-桤塍鬣桁 桤铗铒囔 潆 镫囗桊钼囗 颓, 恹琨忄弪 玎蝠箐礤龛 桤-玎 猁耱痤泐 疣耧噤 桤铗铒钼, 黩 桉觌噱 忸珈铈眍耱 耔眭痤龛玷痤忄螯 镳铞羼 翳玷麇耜钽 疣耧噤 桤铗铒钼 觇礤蜩觐 磬觐镫屙 镳屣囵囹钼 铒篚铍 (翳.1, 牮桠 2).

亦觇 钺疣珙, 潆 镫囗桊钼囗 颓 忄骓 镳彖祗耱忄 镳邃豚汔屐钽 耧铖钺:

忸珈铈眍耱 桤篦囹 滂磬扈牦 磬觐镫屙 恹忮溴龛 犷疣 蝈麇龛 潆栩咫钽 桧蝈疴嚯 怵屐屙 (犷脲 48 ); 恹耦赅 耱噌桦铖螯 疋玷 犷 - 轭.

橡桁屦 2. 碾 镱塍麇龛 桤钺疣驽龛 铒篚铍 镳钼钿桦 忭篁痂狃桧眍 忖邃屙桢 蝮祛痤蝠铒眍泐 犷瘃钿屦驵泐 镳屣囵囹 Na2B12H11SH (BSH), 戾麇眄钽 桧滂赅蝾痦 觐腓麇耱忸 疣滂铋钿铎 (131I-BSH) (嚓蜩忭铖螯 60 礻疏) 豚犷疣蝾痦 骅忸蝽-铒篚铍屙铖栩咫 (禧 戾豚眍祛 -16). 镱祛 耧弼栲朦眍泐 镳桉镱耦犭屙 禧 翳犟桊钼嚯 磬 疣犷麇 耱铍 汔祆-蝾祛沭圄. 襄疴簋 蝾麝 桤戾疱龛 嚓蜩忭铖蜩 桤塍鬣蝈 镳铊玮钿桦 镱祛 汔祆-蝾祛沭圄 麇疱 15-30 扈 祛戾眚 忖邃屙 耦邃桧屙, 黩 镱玮铍弪 铒疱溴腓螯 翦牝桠眍耱 聍弪 汔祆 -蝾祛沭圄 潆 觐黻疱蝽钽 铕汔龛珈. 碾 桉耠邃钼囗 滂磬扈觇 磬觐镫屙 戾麇眍泐 耦邃桧屙 桤戾疱龛 镳钼钿桦 麇疱 20 扈, 1, 3, 6, 9, 12, 24 48 祛戾眚 忖邃屙 (翳.2, 牮桠 1 2). 软蝈疴嚯 玎镨耔 铗溴朦眍泐 桤钺疣驽龛 玎溧忄腓 铗 5 漕 30 扈 钺疣蝽 镳铒铕鲨铐嚯铋 玎忤耔祛耱 铗 疣滂钹牝桠眍耱 戾麇眍泐 耦邃桧屙.项塍麇眄 桤钺疣驽龛 疣耧疱溴脲龛 131l-BSH 玎镨覃忄腓 镟螯 觐祜蝈疣 潆 镱耠邃簋 觐祜蝈痦铋 钺疣犷蜿 (翳.3).

橡桁屦 3. 氧屐 镫囗桊钼囗 颓. 项塍麇眄 疣滂铎弪痂麇耜桢 溧眄 滂磬扈赍 磬觐镫屙 恹忮溴龛 戾麇眍泐 犷瘃钿屦驵泐 耦邃桧屙 (131I-BSH) 镱玮铍 镳邃耱噔栩 嚯泐痂蜢 恹犷疣 疱骅祛 颓.

湾钺躅滂禧 篑腩忤 潆 镳钼邃屙 颓:

1. C铒篚铍(t)/C蜿囗(t)>1;

2. C铒篚铍(t)>minC铒篚铍>羊赅睃(t),

沅 杨矬躅朦(t) 羊赅睃(t) - 觐眦屙蝠圉梃 犷疣 铒篚铍 铌痼驵桴 蜿囗, 礻/ 蜿囗;

min杨矬躅朦 - 扈龛爨朦磬 觐眦屙蝠圉 犷疣 铒篚铍, 镳 觐蝾痤 钺塍麇龛 蝈镫钼 礤轵痤磬扈 纛痨桊箦 翦牝桠眢 镱汶铢屙眢 漕珞.

灶痨箅 潆 疣聍弪 祛铖蜩 漕琨 桤塍麇龛 玎 聍弪 疱嚓鲨 礤轵痤眄钽 玎踱囹 (n+10B --> 7Li+4H+) 桁邋 耠邃簋 忤:

=(杨矬躅朦N/M攀,

沅 - 祛铖螯 漕琨, 衩/;

- 镫铗眍耱 镱蝾赅 蝈镫钼 礤轵痤眍, /(耢2c);

杨矬躅朦 - 觐眦屙蝠圉 10 铒篚铍, / 蜿囗;

N- 麒耠 棱钽噤痤, 6,021023 1/祛朦;

- 祛脲牦痦 爨耨 10, /祛朦;

- 皴麇龛 疱嚓鲨, =383810-24 耢2;

- 屦汨 铗 镳钿箨蝾 疱嚓鲨, =2,34 听;

- 觐翳鲨屙 耦汶囫钼囗 疣珈屦眍耱, =1,610-8 衩疸/听.

如 (翳.2) 耠邃箦:

1) 潆 怵屐屙眍泐 桧蝈疴嚯 0-2 桁邋 戾耱 耔蝮圉 杨矬躅朦(t)/羊赅睃(t)<1, 羊赅睃(t)>杨矬躅朦(t)>min杨矬躅朦, 黩 礤 箐钼脲蜮铕弪 礤钺躅滂禧 篑腩忤 镳钼邃屙 颓;

2) 潆 怵屐屙眍泐 桧蝈疴嚯 2-14 桁邋 戾耱 耔蝮圉 杨矬躅朦(t)>羊赅睃(t)>min杨矬躅朦, 黩 磬痼弪 篑腩忤 2;

3) 潆 怵屐屙眍泐 桧蝈疴嚯 14-26 怦 礤钺躅滂禧 篑腩忤 恹镱腠;

4) 潆 怵屐屙眍泐 桧蝈疴嚯 26-48 桁邋 戾耱 耔蝮圉 min杨矬躅朦>杨矬躅朦(t)>羊赅睃(t), 黩 磬痼弪 篑腩忤 2.

亦觇 钺疣珙, 礤轵痤-玎踱囹眢 蝈疣镨 鲥脲耦钺疣珥 铖簌羼蜮螯 忸 怵屐屙眍 桧蝈疴嚯 14-26 祛戾眚 忖邃屙 犷瘃钿屦驵泐 耦邃桧屙.

碾 磬栳铍邋 铒蜩爨朦眍泐 怵屐屙 磬鬣豚 颓 (麇疱 21 镱耠 忖邃屙 犷瘃钿屦驵泐 耦邃桧屙), 镳 镫铗眍耱 镱蝾赅 蝈镫钼 礤轵痤眍 2,5109 /耢2 觐眦屙蝠圉梃 犷疣 铒篚铍 30 礻/ 祛铖螯 漕琨 桤塍麇龛 玎 聍弪 疱嚓鲨 礤轵痤眄钽 玎踱囹 耦耱噔栩 0,39 灭/扈. 橡 铎 忮腓麒磬 漕琨 铌痼驵桴 蜿囗 耦耱噔栩 25% 镱 耩噔礤龛 漕珙 铒篚铍, 黩 钺羼镥麒 爨犟桁嚯铄 镱疣驽龛 铒篚铍 镳 扈龛爨朦眍 镱怵彐溴龛 铌痼驵桴 蜿囗彘.

义蹴桕-铐铎梓羼赅 翦牝桠眍耱

橡邃豚汔屐铄 蝈蹴梓羼觐 疱龛 钺羼镥麒忄弪 忸珈铈眍耱 桤篦屙 滂磬扈觇 磬觐镫屙 犷疣 铒篚铍 铌痼驵桴 蜿囗 in vivo. 雾 疣聒桊弪 滂囡噻铐 桉耠邃钼囗 磬觐镫屙 犷疣 漕 礤耜铍桴 耋蝾 犭嚆钿囵 忖邃屙棹 铕汔龛珈 戾麇眄钽 疣滂铊钿铎 犷瘃钿屦驵泐 耦邃桧屙. 扬铖钺 镱玮铍弪 筲咫梓栩 镥疱麇睃 桉耠邃箦禧 镳桁屙屐 磬 镳嚓蜩赍 犷瘃钿屦驵 镳屣囵囹钼, 箅篦弪 赅麇耱忸 颓 犭嚆钿囵 恹犷痼 潆 觐黻疱蝽钽 镟鲨屙蜞 铒蜩爨朦眍泐 镱 犷痼 铗眍龛 铒篚铍/铌痼驵桢 蜿囗 蝈 襦禧 耥桄噱 疣滂圉桀眄铄 忸玟彘耱忤 磬 眍痨嚯 蜿囗 镳 钺塍麇龛 蝈镫钼 礤轵痤磬扈. 橡铞邃箴 篑蜞眍怆屙 铒蜩爨朦睇 篑腩忤 潆 颓 耧铖钺耱怏弪 镱恹龛 翦牝桠眍耱 脲麇龛. 橡 铎 珥圜栩咫 箫痤弪 镱溷铗钼栩咫 镳铞邃箴 疱嚯桤圉梃 镳邃豚汔屐钽 耧铖钺 犭嚆钿囵 桉镱朦珙忄龛 汔祆-蝾祛沭圄, 镳栳铕, 漕耱箫眍泐 潆 犷朦眈蜮 戾滂鲨眈觇 鲥眚痤. 襄疱麒耠屙睇 羿牝铕 镱玮铍 镳钼钿栩 桧滂忤潴嚯铄 镫囗桊钼囗桢 颓 镳 脲麇龛 犷朦睇 磬栳铍邋 耠铈睇扈 纛痨囔 珉铌圜羼蜮屙睇 眍忸钺疣珙忄龛 觐礤黜铎 聍弪 耦玟帼 篑腩忤 潆 觌桧梓羼觐泐 镳桁屙屙 颓 磬 耱疣礤.

扬桉铌 腓蝈疣蝮瘥

1. Haritz D., Gabel D., Huiskamp R. Clinical phase-I study of Na2B12H11SH (BSH) in patients with malignant glioma as precondition for boron neutron capture therapy (BNCT). // J. Radiat. Oncol. Biol. Phys., 1994, Vol.28, No.5, P.1175-1181.

2. 丸觇蜩磬 .., 责铍钼 . . 体蝾滂赅 铒疱溴脲龛 10 徼铍钽梓羼觇 钺疣琏圊. // 体滂鲨眈赅 疣滂铍钽. 1981, 1, .44-48.

3. Takagaki M., Oda Y., Miyatake S., Kikuchi H., Kobayashi ., Sakurai Y. , Osawa M. , Mori K., Ono K. Boron neutron capture therapy: preliminary study of BNCT with sodium borocaptate (Na2B12H11SH) on glioblastoma. // J. Neurooncol, 1997, Vol.35, No.2, P.177-185.

4. Moore D. E. A review of techniques for the analysis of boron in the development of neutron capture therapy agents. // J. Pharmaceutical & Biomedical Analysis, 1990, Vol.8, No.7, P.547-553.

5. Raaijmakers .P., Konijnenberg M.W., Dewit L., Haritz D., Huiskamp R. , Philipp K. , Siefert A. Monitoring of blood 10B concentration for boron neutron capture therapy using prompt gamma-ray analysis. // Acta Oncol., 1995, Vol.34, No.4, P.517-523.

6. Imahori Y. , Ueda S., Ohmori Y., Sakae K., Kusuki ., Kobayashi ., Takagaki M., Ono K., Ido T. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas. // Clin. Cancer Res., 1998, Vol.4, No.8, P.1825-1841. 


晕刑铀 惹瘟信遗腿



1. 扬铖钺 镫囗桊钼囗 礤轵痤-玎踱囹眍 蝈疣镨, 怅膻鬣栝 忖邃屙桢 铕汔龛珈 蝮祛痤蝠铒眍泐 镳屣囵囹 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍, 桤戾疱龛 滂磬扈觇 磬觐镫屙 镳屣囵囹 铒篚铍 铌痼驵桴 蜿囗, 铗腓鬣栝 蝈, 黩 忖钿 蝮祛痤蝠铒睇 镳屣囵囹 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍, 戾麇眄 汔祆-桤塍鬣蝈脲, 桤戾 滂磬扈牦 磬觐镫屙 恹忮溴龛 镳屣囵囹 镱祛 汔祆-蝾祛沭圄 恹徼疣 怵屐屙眍 桧蝈疴嚯 潆 镳钼邃屙 礤轲铐-玎踱囹眍 蝈疣镨 镳 篑腩忤, 觐沅 杨矬躅朦(t)/羊赅睃(t)>1 杨矬躅朦(t)>min杨矬躅朦>羊赅睃(t), 沅 杨矬躅朦(t) 羊赅睃(t) - 觐眦屙蝠圉 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍 铒篚铍 铌痼驵桴 蜿囗, min杨矬躅朦 - 扈龛爨朦磬 觐眦屙蝠圉 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍 铒篚铍, 镳 觐蝾痤 钺塍麇龛 蝈镫钼 礤轵痤磬扈 纛痨桊箦 翦牝桠眢 镱汶铢屙眢 漕珞, 疣耨麒螓忄 祛铖螯 漕琨 桤塍麇龛, 镱怆邈铖 疱珞朦蜞蝈 疱嚓鲨 礤轵痤眄钽 玎踱囹.

2. 扬铖钺 镱 . 1, 铗腓鬣栝 蝈, 黩 滂磬扈牦 磬觐镫屙 戾麇眍泐 耦邃桧屙 桉耠邃簋 滂囡噻铐 铗 祛戾眚 忖邃屙 漕 48 .

3. 扬铖钺 镱 . 1, 铗腓鬣栝 蝈, 黩 祛铖螯 漕琨 铒疱溴 镱 耦铗眍龛 = (杨矬躅朦NA/)攀, 沅 - 祛铖螯 漕琨, 衩/; - 镫铗眍耱 镱蝾赅 蝈镫钼 礤轵痤眍, /(c2c); NA - 麒耠 棱钽噤痤; - 祛脲牦痦 爨耨 蹊扈麇耜钽 屐屙蜞 恹耦觇 皴麇龛屐 玎踱囹 蝈镫钼 礤轵痤眍; - 皴麇龛 玎踱囹 蝈镫钼 礤轵痤眍, 耢2; - 屦汨 铗 镳钿箨蝾 疱嚓鲨, 听; - 觐翳鲨屙 耦汶囫钼囗 疣珈屦眍耱彘 - 1,610-8衩疸/听.